Abstract
Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER alpha and ER beta selective analogs.
MeSH terms
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Estrogen Receptor alpha / chemistry
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Estrogen Receptor beta / chemistry
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Female
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Humans
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Inhibitory Concentration 50
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Ligands
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Protein Binding
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Selective Estrogen Receptor Modulators / chemical synthesis*
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Selective Estrogen Receptor Modulators / pharmacology
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Structure-Activity Relationship
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Tetrahydroisoquinolines / chemical synthesis
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Tetrahydroisoquinolines / pharmacology*
Substances
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Estrogen Receptor alpha
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Estrogen Receptor beta
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Ligands
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Selective Estrogen Receptor Modulators
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Tetrahydroisoquinolines